Structure of the reovirus core at 3.6?Å resolution
Top Cited Papers
- 27 April 2000
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 404 (6781) , 960-967
- https://doi.org/10.1038/35010041
Abstract
The reovirus core is an assembly with a relative molecular mass of 52 million that synthesizes, modifies and exports viral messenger RNA. Analysis of its structure by X-ray crystallography shows that there are alternative, specific and completely non-equivalent contacts made by several surfaces of two of its proteins; that the RNA capping and export apparatus is a hollow cylinder, which probably sequesters its substrate to ensure completion of the capping reactions; that the genomic double-stranded RNA is coiled into concentric layers within the particle; and that there is a protein shell that appears to be common to all groups of double-stranded RNA viruses.Keywords
This publication has 43 references indexed in Scilit:
- Posttranslational Quality Control: Folding, Refolding, and Degrading ProteinsScience, 1999
- [20] Processing of X-ray diffraction data collected in oscillation modePublished by Elsevier ,1997
- The 1.85 Å Structure of Vaccinia Protein VP39: A Bifunctional Enzyme That Participates in the Modification of Both mRNA EndsCell, 1996
- Universal Catalytic Domain Structure of AdoMet-dependent MethyltransferasesJournal of Molecular Biology, 1995
- Fungal Virus Capsids, Cytoplasmic Compartments for the Replication of Double-stranded RNA, Formed as Icosahedral Shells of Asymmetric Gag DimersJournal of Molecular Biology, 1994
- The CCP4 suite: programs for protein crystallographyActa Crystallographica Section D-Biological Crystallography, 1994
- Subcore- and core-like particles of Broadhaven virus (BRDV), a tick-borne orbivirus, synthesized from baculovirus expressed VP2 and VP7, the major core proteins of BRDVVirus Research, 1994
- Crystallization of the reovirus type 3 dearing core crystal packing is determined by the λ2 proteinJournal of Molecular Biology, 1990
- Three-dimensional structure of rotavirusJournal of Molecular Biology, 1988
- Packaging of DNA into bacteriophage heads: A modelJournal of Molecular Biology, 1983