HYDROCARBON NEUROPATHY

Publisher Website
Google Scholar
Abstract
Peripheral polyneuropathy has been described in individuals exposed to certain hydrocarbon solvents including hexane, petroleum benzine and mixtures containing both hexane and toluene. The disease involves motor and sensory changes with a symmetrical and ‘strxking-glove’ distribution. Studies in animals have reproduced this effect with both hydrcarbons and methyl n-butyl ketone. A possible common metabolite such as 2,5-hexanedione has been postulattd as a potential neurotoxic agent. This review includes comments on chernicallyinduced peripheral neuropathies, clinical reports of hydrocarbon neuropathy from hexane and solvent blends, experimental studies in animals, collateral studies on oxygenated solvents and metabolites and comments on possible mechanisms.

This publication has 0 references indexed in Scilit: