SLIDE LATEX FIXATION TEST
- 13 September 1958
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 168 (2) , 180-181
- https://doi.org/10.1001/jama.1958.63000020008007d
Abstract
The use of uniform size polystyrene latex particles as substitutes for red blood cells in the serologic test for rheumatoid arthritis has been reported on previously.1These biologically inert particles might agglutinate spontaneously without added gamma globulin in the presence of strongly positive rheumatoid serum, but only in a low titer.2When serums were fractionated by the addition of 1.64 M ammonium sulfate, 90% of 250 patients with rheumatoid arthritis showed positive results in a one-tube technique with use of the patient's own gamma globulin.2aAs a further simplification, Bozicevich and co-workers3have described a slide method using serum and bentonite particles. A study has now been made which has resulted in a simple screening test which is highly sensitive for the diagnosis of rheumatoid arthritis and suitable for epidemiologic study, as well as for clinical and office use. Materials and Methods A stock solution ofKeywords
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