Association of severe haemophilia A and factor V Leiden: report of three cases
- 1 January 1996
- journal article
- Published by Wiley in Haemophilia
- Vol. 2 (1) , 51-53
- https://doi.org/10.1111/j.1365-2516.1996.tb00011.x
Abstract
The clinical severity of haemophilia is usually related to residual clotting factor activity. Reports of factor V deficiency or protein C have been described in haemophilic patients and both are involved in the activated protein C pathway. Recently, the poor response to activated protein C due to factor V Leiden (FQ506) has been associated with an increased risk of thrombosis and its incidence in the normal population is given as 2-7%. We describe three cases of severe haemophilia A heterozygous for factor V Leiden and its influence on phenotype.Keywords
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