Thep-Hydroxylation of Amphetamine and Phentermine by Rat Liver Microsomes
- 1 January 1975
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 5 (9) , 531-538
- https://doi.org/10.3109/00498257509056123
Abstract
1. The products of p-hydroxylation of amphetamine and phentermine by two different preparations of rat liver microsomes were identified and quantitatively determined. At low concentrations (μM) significant proportions of the substrates were metabolized to the p-hydroxy derivatives by an NADPH-dependent system. The enzyme system was inhibited by higher substrate concentrations (mM) and was not induced by either phenobarbital or 3-methyl-cholanthrene. 2. The properties of this in vitro system are consistent with reports on in vivo studies of this reaction.Keywords
This publication has 13 references indexed in Scilit:
- Hydroxylation of amphetamine to parahydroxyamphetamine by rat liver microsomesBiochemical Pharmacology, 1974
- The hydroxylation of D-amphetamine by liver microsomes of the male ratBiochemical Pharmacology, 1974
- A specific gas chromatographic method for the detection of p-hydroxyamphetamine and p-hydroxynorephedrine in brain tissueJournal of Chromatography A, 1973
- Application of Quantitative GC–Mass Spectrometry to Study of Pharmacokinetics of Amphetamine and PhentermineJournal of Pharmaceutical Sciences, 1973
- Isolation of rat liver microsomes by gel filtrationAnalytical Biochemistry, 1973
- Effect of diethylaminoethyl diphenylpropylacetate hydrochloride (SKF-525A) on the norepinephrine-depleting actions of d-amphetamineBiochemical Pharmacology, 1971
- Inhibition of the hepatic metabolism of amphetamine by desipramineBiochemical Pharmacology, 1969
- Influence of various psychoactive drugs on the in vivo metabolism of d-Amphetamine in the ratEuropean Journal of Pharmacology, 1969
- Hydroxylation-induced migrations of tritium in several substrates of liver aryl hydroxylasesArchives of Biochemistry and Biophysics, 1967
- Inhibition of the metabolism of hexobarbital in vitroBiochemical Pharmacology, 1960