Effect of splanchnicotomy on the renal excretion of inorganic phosphate in the anaesthetized dog

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Abstract
The effects of acute i.v. inorganic phosphate (P i ) loading were studied on nembutalized mongrel dogs previously subjected to unilateral splanchnicotomy (“renal denervation”). GFR (51Cr-EDTA) was not different on the intact and the denervated side, while urine output (V), sodium excretion (UNaV), and urinary excretion (UP i V) of inorganic phosphate of denervated kidneys were significantly increased at any plasma P i level. Thus, tubular reabsorption of P i in denervated kidneys was considerably depressed. Tubular transport rates of Na and P i —as expressed in per cent of the filtered load—were positively correlated in both intact and denervated organs. Besides an impairment in tubular transport of Na a depression in the reabsorption of inorganic phosphate is brought about by renal denervation. A common mechanism of action for both Na and P i can be supposed.