Syngeneic bone marrow transplantation eliminates Vβ8.2 T lymphocytes from the spinal cord of Lewis rats with experimental allergic encephalomyelitis
- 1 July 1995
- journal article
- research article
- Published by Wiley in Journal of Neuroscience Research
- Vol. 41 (4) , 526-531
- https://doi.org/10.1002/jnr.490410412
Abstract
Experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis (MS), is a paralytic disease of the central nervous system (CNS) mediated by T‐lymphocytes reactive to myelin basic protein (MBP). Lewis rats actively immunized with fragment 68 to 82 of guinea pig MBP develop a monophasic disease with spontaneous recovery. Lymphocyte recognition of the primary encephalitogenic sequence of MBP (fragment 68 to 82) is Vβ8.2 T cell receptor (TCR) skewed [1–3]. Lewis rats in clinical remission at 1 month and 3 months after spontaneous resolution of EAE retain Vβ8.2 T‐lymphocytes in the CNS when analyzed by reverse transcriptase polymerase chain reaction or in situ hybridization. In contrast, I and 3 months after clinical remission from syngeneic bone marrow transplantation, Vβ8.2 T lymphocytes are absent from the CNS. During clinically active EAE and inflammatory breakdown of the blood‐brain barrier, immune ablation and reconstitution with syngeneic bone marrow results in clinical tolerance of the new immune system to myelin.Keywords
This publication has 25 references indexed in Scilit:
- Modulation of EAE by vaccination with T cell receptor peptides: Vβ8 T cell receptor peptide-specific CD4+ lymphocytes lack direct immunoregulatory activityJournal of Neuroimmunology, 1993
- Human T cell autoimmunity against myelin basic protein: CD4+ cells recognizing epitopes of the T cell receptor β chain from a myelin basic protein‐specific T cell cloneEuropean Journal of Immunology, 1993
- Direct demonstration of the infiltration of murine central nervous system by Pgp-1/CD44high CD45RBlow CD4+ T cells that induce experimental allergic encephalomyelitisJournal of Neuroimmunology, 1992
- T Cell Receptor Peptide Therapy Triggers Autoregulation of Experimental EncephalomyelitisScience, 1991
- Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitisNature, 1989
- Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different.The Journal of Experimental Medicine, 1989
- Bone marrow transplantation (BMT) versus immunosuppression for the treatment of severe aplastic anaemia (SAA): a report of the EBMT* SAA Working PartyBritish Journal of Haematology, 1988
- Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapyCell, 1988
- Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune interventionCell, 1988
- A suppressor T-lymphocyte cell line for autoimmune encephalomyelitisNature, 1988