Clinical evidence is accumulating that abrupt withdrawal of meprobamate (Miltown, Equanil) from patients who have been ingesting large amounts of this agent may be followed by major convulsions. Lemere1 reported the case of a patient who had ingested 6.4 gm. of meprobamate daily for one month and had a convulsion 10 hours after discontinuation of the drug. Barsa and Kline2 noted a single convulsion in 6 of 25 schizophrenic patients following withdrawal of meprobamate (2.4 gm. daily for nine months). Tucker and Wilensky3 reported one grand mal seizure, following discontinuation of the drug, in 2 of 32 psychotic patients who had received 1.6 gm. of meprobamate, increasing to 4.8 gm., daily for three months. Two cases of this sort have also been observed at the U. S. Public Health Service Hospital, Lexington, Ky.4 One patient, who had been taking 4.0 gm. of meprobamate daily for about