Interceptive Activity of 16α-Bromoacetoxyprogesterone

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Abstract
A local delivery system was utilized to study interruption of pregnancy during the postimplantation period in rats. Intrauterine insertion of control silastic gels in the right cornua on Day 7 of pregnancy had no significant effect on fetal survival. 16α-Bromoacetoxyprogesterone (l6α-BAP) and 1lα-bromoacetoxyprogesterone (llα-BAP) were effective (p > 0.02) in causing fetal resorptions when applied in similar silastic gels. No contralateral effect was observed with 16α-BAP or 1lα-BAP. The other affinity labeling steroids used in this study, 2α-bromoacetoxyprogesterone, 6β-bromoacetoxyprogesterone, 21-bromoacetoxyprogesterone, 2α-bromoprogesterone, 6β-bromoprogesterone, and the structural analog, 16α-acetoxyprogesterone did not cause fetal resorption. Intrauterine application of 16α-BAP significantly inhibited uterine uptake of systemically administered [3H]progesterone in nonpregnant rats, while 2α-bromoacetoxyprogesterone had no such effect. 16α-BAP may act as a competitive antiprogestogen, covalently bonding to the progesterone receptor and excluding endogenous progesterone. This interceptive agent is capable of locally interrupting early pregnancy in the rat and does not appear to produce subsequent effects on reproductive patterns.

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