SUB-ACUTE SCLEROSING PANENCEPHALITIS - CASE WITH A PROLONGED COURSE IN AN ADULT - ISOLATION AND CHARACTERISTICS OF A DEFECTIVE MEASLES-VIRUS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 135  (10) , 653-663
Abstract
A 33 yr old man had a 6 yr history of clinical signs suggesting multiple sclerosis: visual lesion at 27 yr of age, cerebellar and visual disturbances at 31 which partly regressed, lymphocytosis and increased .gamma.-globulin levels in the CSF. Biological and anatomical (optical and ultrastructural) examinations gave results typical of a subacute sclerosing panencephalitis. A cytopathogenic measles virus was isolated from a cerebral biopsy specimen. The agent was transmissable to Vero [African green monkey kidney] cells by co-culture but infectivity was always related to the cells and was therefore an incomplete viral infection. Virus-like particles were found in the nucleus and cytoplasm after EM examination of the co-cultures. Biochemical tests demonstrated that the viral proteins were all synthesized except hemagglutinin, which is a characteristic abnormality of a defective measles virus.

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