DERIVATIVES OF 4-AMINO-PYRIDINE AS SELECTIVE THROMBIN INHIBITORS
- 1 May 1997
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 7 (10) , 1283-1288
- https://doi.org/10.1016/s0960-894x(97)00210-2
Abstract
No abstract availableThis publication has 14 references indexed in Scilit:
- Enzyme flexibility, solvent and ‘weak’ interactions characterize thrombin–ligand interactions: implications for drug designStructure, 1996
- D-Phe-Pro-p-Amidinobenzylamine: A potent and highly selective thrombin inhibitorBioorganic & Medicinal Chemistry Letters, 1996
- Design principles for orally bioavailable drugsDrug Discovery Today, 1996
- Syntheses and Selective Inhibitory Activities of Terphenyl‐Bisamidines for Serine ProteasesArchiv der Pharmazie, 1996
- Serine protease selectivity of the thrombin inhibitor D-Phe-Pro-Agmatine and its homologsBioorganic & Medicinal Chemistry Letters, 1995
- Refined 2·3ÅX-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA: A starting point for improving antithromboticsJournal of Molecular Biology, 1992
- Geometry of binding of the benzamidine‐ and arginine‐based inhibitors Nα‐(2‐naphthyl‐sulphonyl‐glycyl)‐dl‐p‐amidinophenylalanyl‐piperidine (NAPAP) and (2R,4R)‐4‐methyl‐1‐[Nα‐(3‐methyl‐1,2,3,4‐tetrahydro‐8‐quinolinesulphonyl)‐l‐arginyl]‐2‐piperidine carboxylic acid (MQPA) to human α‐thrombinEuropean Journal of Biochemistry, 1990
- Comparative Studies on the Inhibition of Trypsin, Plasmin, and Thrombin by Derivatives of Benzylamine and BenzamidineEuropean Journal of Biochemistry, 1968
- Polychloroaromatic compounds. Part IV. Oxidation of 2- and 4-N-alkylaminotetrachloropyridines and nucleophilic substitution of tetrachloronitropyridinesJournal of the Chemical Society C: Organic, 1968
- Inhibition of Proteolytic Enzymes by Decarboxylated Amino-Acid Derivatives. Effect of Toluenesulphonyl(Tosyl)agmatine (4-Toluenesulphonamidobutylguanidine) on Thrombin and TrypsinNature, 1961