Influence of restricted diet on the cell cycle in the crypt of mouse small intestine.

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Abstract
The small intestine of mice adapted to dietary restriction had low mitotic activity in the crypts. There was no marked difference in the villus and crypt cell numbers but the migrating speed from crypt to villus decreased and the transit time was prolonged. The cell cycle of the proliferative cells in the crypts were studied to determine if it alters when the mitotic activity decreases. There are differences in cell cycle and labeling index between the unrestricted animals and restricted animals. The cycle time of the duodenal and jejunal cells particularly of G1 phase was prolonged under dietary restriction. The prolongation of cycle time was not found in the ileum. The proliferative cell number principally controls mitotic activity in the crypts. Reduction of the proliferative cell number will be accounted for by the increase of resting cells in G1 phase.