Studies on the Site of Synthesis of Transcobalamin-II
- 1 March 1968
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 127 (3) , 740-744
- https://doi.org/10.3181/00379727-127-32789
Abstract
The liver, kidneys, and stomach were studied to determine the site of transcobalamin-n synthesis. The kidney is not the site since total nephrectomy had no effect on the reappearance of TC-n after saturation of TC-II with B12. Total gastrectomy also had little effect on TC-II levels or rate of synthesis. The liver proved to be the site of TC-n synthesis because destruction of liver with CC1 resulted in a decrease of serum TC-n and unsaturated TC-n in the blood after saturation with cyanocobalamin was markedly low in the CC1 treated animals. TC-n was also synthesized by the perfused rat liver.This publication has 2 references indexed in Scilit:
- Studies on the interaction of vitamin B12: Intrinsic factor and receptorsArchives of Biochemistry and Biophysics, 1965
- An in vitro assay for intrinsic factor activity of porcine mucosal concentratesAnalytical Biochemistry, 1964