Synthesis of Macrocyclic Enediynes by Twofold C-Alkylation
- 1 April 1996
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1996 (04) , 446-448
- https://doi.org/10.1055/s-1996-4239
Abstract
The alkylation of malonate derivatives with the new bis-electrophile 4 gave 18-membered macrocyclic enediynes 6a-c by a 2:2 alkylation process. The thermal stability of the bis(enediyne) 6a was investigated by differential scanning calorimetry. X-ray structure analyses revealed chair and twisted conformations of the macrocycles 6b and 6c in the crystal.Keywords
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