Tales of two similar hypotheses: the rise and fall of chemical and radiation hormesis
- 1 January 2000
- journal article
- research article
- Published by SAGE Publications in Human & Experimental Toxicology
- Vol. 19 (1) , 85-97
- https://doi.org/10.1191/096032700678815620
Abstract
This paper compares the historical developments of chemical and radiation hormesis from their respective inceptions in the late 1880‘s for chemical hormesis and early 1900‘s for radiation hormesis to the mid 1930‘s to 1940 during which both hypotheses rose to some prominence but then became marginalized within the scientific community. This analysis documents that there were marked differences in their respective temporal developments, and the direction and maturity of research. In general, the formulation of the chemical hormesis hypothesis displayed an earlier, more-extensive and more sophisticated development than the radiation hormesis hypothesis. It was able to attract prestigious researchers with international reputations from leading institutions, to be the subject of numerous dissertations, to have its findings published in leading journals, and to have its concepts incorporated into leading microbiological texts. While both areas became the object of criticism from leading scientists, the intensity of the challenge was greatest for chemical hormesis due to its more visible association with the medical practice of homeopathy. Despite the presence of legitimate and flawed criticism, the most significant limitations ofboth chemical and radiation hormesis and their respective ultimate undoing were due to their: (1) lack of development of a coherent doseresponse theory using data of low dose stimulation from both the chemical and radiation domains; (2) difficulty in replication of low dose stimulatory responses without an adequate study design especially with respect to an appropriate number and properly spaced doses below the toxic threshold; (3) modest degree of stimulation even under optimal conditions which was difficult to distinguish from normal variation; and (4) lack of appreciation of the practical and/or commercial applications of the concepts of low dose stimulation.Keywords
This publication has 69 references indexed in Scilit:
- A scientific reappraisal of the ‘principle of similarity’Medical Hypotheses, 1997
- A quantitatively‐based methodology for the evaluation of chemical hormesisHuman and Ecological Risk Assessment: An International Journal, 1997
- On the Alleged Stimulating Action of X-Rays Upon PlantsAmerican Journal of Botany, 1931
- THE EFFECT OF RADIANT ENERGY ON GROWTH AND SPORULATION IN COLLETOTRICHUM PHOMOIDESCanadian Journal of Research, 1930
- EXPERIMENTAL STUDIES WITH SMALL DOSES OF X RAYS.The Lancet, 1919
- Toxic Inorganic Salts and Acids as Affecting Plant Growth (Preliminary Communication)Botanical Gazette, 1913
- The alcoholic ferment of yeast-juice. Part VI.—The influence of arsenates and arsenites on the fermentation of the sugars by yeast-juiceProceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character, 1911
- The Toxic Action of Certain Organic Plant ConstituentsBotanical Gazette, 1908
- Toxic Limits and Stimulation Effects of Some Salts and Poisons on WheatBotanical Gazette, 1907
- On the Toxic Action of Dissolved Salts and Their Electrolytic DissociationBotanical Gazette, 1896