Antibody-Mediated Secondary Eosinophilic Response to Taenia taeniaeformis in the Rat

Publisher Website
Google Scholar
Abstract
Normal rats were given i.v. doses of immune serum or immunoglobulin [Ig] fractions 24 h before oral challenge with 1000 eggs of T. taeniaeformis. Total eosinophil counts per cubic millimeter were performed for 3 days prior to and 6 days after challenge. Sensitized rats usually showed sharp peaks of eosinophilia 2-6 days after this dose. The pattern of the eosinophilic response was similar to that which occurs after challenge of immune infected rats. The differences in peripheral eosinophil levels in passively immunized and normal rats were statistically significant. Ig fractions containing protective IgG2a were most effective, but a fraction containing reaginic antibody activity also sensitized rats to give secondary eosinophilic responses. The findings are discussed in relation to the probable contribution of antigen-antibody reactions to the production of secondary eosinophilic responses in experimental cysticercosis.

This publication has 0 references indexed in Scilit: