Toxic effect of elemental phosphorus on L-cells cultivated in suspension

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Abstract
The effects of elemental phosphorus upon cell replication and cellular morphology were tested on L-cells grown in spinner culture. The cell replication was completely inhibited by the presence of elemental phosphorus in the culture medium at 1.25 mg/1. At 0.31 mg/1, 74% inhibition of the cell replication was observed. A calculated correlation coefficient between the percentage inhibition and the phosphorus concentration was valid at the 1% level.The phosphorus significantly altered the cellular morphology. The affected cells showed ballonization, loss of stain-binding capacity, disintegration of cytoplasm, enlarged nuclei with vacuolated nucleoli, and formation of multiple nucleated giant cells. A possible sequence of the changes was discussed.

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