The Anion Gap in Asymptomatic Plasma Cell Dyscrasias

Abstract
The presence of a low anion gap in patients with multiple myeloma was recently emphasized. This was related to the retention of Cl and HCO3 anions to offset the cationic charge of the monoclonal immunoglobulins. This paper reports the presence of a low anion gap in 50 patients with asymptomatic plasma cell dyscrasias. No correlation was found between the size of the anion gap and the height of the paraprotein spike or the size of the anion gap and an index of the net cationic charge of the monoclonal immunoglobulins.

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