A linkage study of the locus for X-linked Charcot-Marie-Tooth disease

28 June 2008

journal article
research article
Published by Wiley in Clinical Genetics

Vol. 33 (6) , 435-440
https://doi.org/10.1111/j.1399-0004.1988.tb03477.x

Abstract

A large family with Charcot-Marie-Tooth disease, showing a probable X-linked incomplete dominant inheritance, was studied by linkage analysis. Results, obtained by the use of X chromosome specific DNA probes of known regional location, suggest that the disease locus is linked to the DXYS1 locus (.cxa.z = 2.59 at .cxa..theta. = 0.00) and to the DXS14 locus and, places the disease locus between the DXYS1 locus and the DXS14 locus, near the centromere of the X chromosome. Together with the published data, a distance of 13 cM (.cxa.z = 6.95) was assessed between the disease locus and the DXYS1 locus.

Keywords

This publication has 10 references indexed in Scilit:

A family with Charcot-Marie-Tooth's disease, showing a probable X-linked incompletely dominant inheritance
Hereditas, 2008
Detection of specific sequences among DNA fragments separated by gel electrophoresis
Published by Elsevier ,2006
Prenatal diagnosis of X-linked choroideremia with mental retardation, associated with a cytologically detectable X-chromosome deletion
Human Genetics, 1987
X‐linked neuropathy: Gene localization with DNA probes
Annals of Neurology, 1986
X-linked dominant Charcot-Marie-Tooth disease: Suggestion of linkage with a cloned DNA sequence from the proximal Xq
Human Genetics, 1985
Report of the committee on the genetic constitution of the X and Y chromosomes
Cytogenetic and Genome Research, 1985
Charcot-Marie-Tooth Disease with Sex-Linked Inheritance, Linkage Studies and Abnormal Serum Alkaline Phosphatase Levels
European Neurology, 1978
Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.
Proceedings of the National Academy of Sciences, 1977
Linkage relations of locus for X-borne type of Charcot-Marie-Tooth muscular atrophy and that for Xg blood groups.
Journal of Medical Genetics, 1976
Genetic and clinical aspects of Charcot‐Marie‐Tooth's disease
Clinical Genetics, 1974