Coupled Ion and Fluid Transport in the Kidney

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Abstract
THE ability of the kidney to transfer electrolytes and water across the tubular epithelium has a key role in the regulation of body fluids. As large amounts of extracellular fluid are filtered continuously by the glomerulus, the constancy in the composition of the body fluids depends critically on the reabsorption of all but a small portion of the filtered load of electrolyte and water. In addition, parts of the nephron help control body-fluid composition by the net addition of specific ions to the tubular fluid — i.e., by secretory transport operations.Many tubular reabsorptive and secretory transport processes are functionally . . .