Effects of a Progestin Estrogen Preparation on Blood Coagulation Mechanisms

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Abstract
THE WIDESPREAD use of oral progestins for fertility control has stimulated interest in the possible effects of these compounds on blood coagulation mechanisms. Questions of this nature arise from the fact that studies of blood coagulation components during pregnancy, and after oral administration of estrogens, have revealed changes and variations in the levels of some of the coagulation factors. High normal levels of factor I (fibrinogen), factor II (prothrombin) factor VII (proconvertin), factor IX (plasma thromboplastin components), and factor X (Stuart Factor) have been reported for pregnant women.1Elevated levels of factor II (prothrombin ) and factor V ( accelerator globulin) have been observed after intravenous administration of conjugated estrogens.2Recently, it has been reported that oral administration of estrogen preparations, as well as orally active progestins, appear to cause an increase in profibrinolysin, antifibrinolysin, and fibrinogen (factor I).3,4 This investigation was undertaken to obtain further information concerning the

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