Rh18 and hr^S Blood Groups and Antibodies

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Abstract
Anti-hr^S also known as the Shabalala antibody, is unlikely to be found in unabsorbed human serum. The term ‘anti-hr^S’ was devised by Shapiro in 1960 to describe the antibodies remaining in the absorbed serum after anti-Rh18 had been absorbed with R(2)R(2) red cells. R(2)R(2)-absorbed anti-Rh18 (anti-hr^S), although an interesting research tool, is therefore clinically irrelevant. Unabsorbed anti-Rh18, on the other hand, is a clinically significant antibody. It is compatible not only with Rh-‘deleted’ and Rh(null) red cells, as described by Shapiro, but is also compatible with the red cells of numbers of Southern African Blacks and Coloureds (mixed race) who have R(0), R(0)^U or R(2)r phenotypes. Anti-Rh18 causes haemolytic disease of the newborn and, when uncontaminated with other antibodies, is a further reagent for resolving Rh grouping problems.

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