Importance of Testes in Induction of Hyperplastic Nodules, Carcinomas, and Cirrhosis of Liver in A × C Male Rats Ingesting 0.025% N-2-Fluorenyldiacetamide
- 1 September 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 53 (3) , 883-886
- https://doi.org/10.1093/jnci/53.3.883
Abstract
The dependence of hepatic carcinogenesis on the testes was studied in inbred A × C male rats ingesting 0.025% N-2-fluorenyldiacetamide (F-diAA). The experimental groups consisted of intact rats with normal testes, rats with 1 normal testis, rats with 1 atrophic testis related to a congenital defect, and rats without testes. The incidence of carcinomas and the number of rats with large carcinomas, multiple carcinomas, and metastases were highest in intact rats. The incidence and size not only decreased in animals with 1 or both testes removed, but also the decrease was directly related to the bulk and weight of the testis in rats in the other groups. The incidence was lowest in rats with both testes removed. This experiment confirmed the importance of the testes in F-diAA hepatic carcinogenesis, and also demonstrated the extreme sensitivity of the liver to the level of male sex hormone.Keywords
This publication has 0 references indexed in Scilit: