Freund's adjuvants: relationship of arthritogenicity and adjuvanticity in rats to vehicle composition.

  • 1 August 1974
    • journal article
    • Vol. 27  (2) , 311-30
Abstract
Over a hundred compounds and natural materials were examined for their ability to induce arthritis in rats when mixed with heat-killed delipidated Mycobacteria tuberculosis. Many of these materials were also assessed for (CMI) adjuvant activity by their ability to induce allergic encephalomyelitis (EAE) in rats when mixed with guinea-pig spinal cord, both with and without added M. tuberculosis.