Occurrence of permanent anovulation in mouse ovaries and permanent changes in the vaginal and uterine epithelia following neonatal treatment with large doses of 5.ALPHA.-dihydrotestosterone.

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Abstract
Female mice of the C57BL/Tw strain were injected daily with 1 .mu.g estradiol-17.beta. (E2), 1 or 5 .mu.g testosterone (T) and 5.alpha.-dihydrotestosterone (5.alpha.-DHT), the dose being increased varying from 5-100 .mu.g for 5 days from the day of birth. These mice were ovariectomized at 90 days of age and kept for 50 days until sacrifice. Permanent-anovulatory ovaries were found in 30-40% of mice treated neonatally with large doses of 5.alpha.-DHT. All of the E2-treated and 42% of the 5 .mu.g T-treated mice showed permanent anovulation in the ovaries at 90 days of age, while none of the 1 .mu.g T-treated mice had such anovulatory ovaries. Estrogen-independent, permanent vaginal changes occurred in mice receiving injections of 5 .mu.g T or 5-100 .mu.g 5.alpha.-DHT, but not in those given the injections of 1 .mu.g T.

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