EFFECTS OF ADRENERGIC AGONISTS AND BLOCKERS ON ANTIGEN-INDUCED DNA-SYNTHESIS INVITRO

  • 1 January 1977
    • journal article
    • research article
    • Vol. 26  (1) , 36-42
Abstract
The effects of both .alpha. and .beta. adrenergic agonists and blockers on antigen-stimulated DNA synthesis in human lymphocyte cultures were studied. Antigen-induced responses appeared to be enhanced by the presence of the .beta. blockers, propranolol and dichloroisoproterenol. This effect appeared to be related to specific blocking of the lymphocyte .beta. receptor since D (+) propranolol, a compound devoid of such activity, has no effect. Similarly, an .alpha.-adrenergic agonist such as norepinephrine enhanced lymphocyte responsiveness. [The study of agents which enhance the immune response have practical applications of increasing the efficacy of protective immunizations and have potential use in the immunotherapy of cancer.].

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