The mitomycin bioreductive antitumor agents: Cross-linking and alkylation of DNA as the molecular basis of their activity
- 1 October 1997
- journal article
- review article
- Published by Elsevier in Pharmacology & Therapeutics
- Vol. 76 (1-3) , 73-87
- https://doi.org/10.1016/s0163-7258(97)00088-0
Abstract
No abstract availableKeywords
This publication has 78 references indexed in Scilit:
- Bioactivation of mitomycin antibiotics by aerobic and hypoxic Chinese hamster ovary cells overexpressing DT-diaphoraseBiochemical Pharmacology, 1996
- SR 4233 (Tirapazamine): a new anticancer drug exploiting hypoxia in solid tumoursBritish Journal of Cancer, 1993
- Effect of site specifically located mitomycin C-DNA monoadducts on in vitro DNA synthesis by DNA polymerasesBiochemistry, 1993
- Novel interstrand cross-links induced by the antitumor antibiotic carzinophilin/azinomycin BJournal of the American Chemical Society, 1992
- Isolation and structure of an intrastrand cross-link adduct of mitomycin C and DNABiochemistry, 1992
- Structural, conformational, and theoretical binding studies of antitumor antibiotic porfiromycin (N-methylmitomycin C), a covalent binder of DNA, by x-ray, NMR, and molecular mechanicsJournal of Medicinal Chemistry, 1990
- Recognition between mitomycin C and specific DNA sequences for cross-link formationBiochemistry, 1990
- Duplex oligodeoxyribonucleotides crosslinked by mitomycin C at a single site: synthesis, properties, and crosslinkBiochemistry, 1990
- Relationships between functionality and genetic toxicology of selected DNA-damaging agentsMutation Research/Reviews in Genetic Toxicology, 1984
- DNA methylation and the frequency of CpG in animal DNANucleic Acids Research, 1980