BACTERIA ASSOCIATED WITH ACUTE OTITIS MEDIA HAVE HIGH Clq BINDING CAPACITY

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Abstract
A simple, rapid and sensitive radioimmunologic method for demonstrating C1q [q fraction of complement component 1] binding to bacteria is described. Various bacteria were shown to bind C1q without the participation of antibodies. Great differences in C1q binding levels between different types and strains of Streptococcus pneumoniae were found. A high uptake of C1q was observed for many pneumococcal strains of type VI, XIX and XXIII and also for non-typable strains of Haemophilus influenzae and Branhamella catarrhalis. Other bacteria tested, including H. influenzae types a-f, demonstrated less capacity to bind C1q.