Effect of Dietary Oleate and Linoleate on the Distribution of Fatty Acids in Mouse Triglycerides

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Abstract
Oleic acid and linoleic acid were predominantly esterified at the β position of normal mouse triglycerides, whereas myristic acid, palmitic acid and stearic acid were more apt to be found in an α position. Palmitoleic acid was noted to be uniformly distributed in the triglycerides. Deposition in the α position accounted for the greatest part of the increase in depot fat level of oleic and linoleic acids that accompanied the feeding of these acids. With high dietary linoleate levels the normal linoleic acid distribution was reversed and the amount in a single α position exceeded that of the β position. When mice were fed a fat-free diet, two rates of disappearance were observed for linoleic acid esterified at the α positions whereas only the slower rate was noted for β-esterified linoleic acid. These results support the thesis that the glycerides of depot fat are not formed in a uniform or random manner.