Influence of Feeding and Sham Feeding upon Serum Gastrin and Gastric Acid Secretion in Control Subjects and Duodenal Ulcer Patients

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Abstract
Mayer, G., Arnold, R., Feurle, G., Fuchs, K., Ketterer, H., Track, N. S. & Creutzfeldt, W. Influence of feeding and sham feeding upon serum gastrin and gastric acid secretion in control subjects and duodenal ulcer patients. Scand. J. Gastroent. 1974, 9, 703–710. Serum immunoreactive gastrin (1RG) levels increased significantly more, after a standard liquid meal, in duodenal ulcer (DU) patients than in healthy controls, while fasting levels did not differ. A modified sham feeding (MSF) procedure regularly stimulated gastric acid secretion both in DU patients and controls. The mean serum IRG response of DU patients to MSF was significantly greater than the slight response of the controls. There is no obvious explanation for the increased IRG release after feeding or MSF in DU patients. No correlation was found between the gastric acid response to MSF and the IRG output in DU patients and controls. The results suggest that acid secretion after vagal stimulation in man is mainly achieved by direct effects upon the parietal cells, and that vagally released IRG does not contribute significantly to the amount of acid secreted after vagal stimulation.