The role of C-reactive protein as a prognostic indicator in advanced cancer
Top Cited Papers
- 1 June 2002
- journal article
- review article
- Published by Springer Nature in Current Oncology Reports
- Vol. 4 (3) , 250-255
- https://doi.org/10.1007/s11912-002-0023-1
Abstract
C-reactive protein (CRP) is a nonspecific but sensitive marker of inflammation. Interleukin-6 (IL-6), IL-1, and tumor necrosis factor á induce the synthesis of CRP in hepatocytes. Increased CRP level is considered to be an important risk factor for atherosclerosis, myocardial infarction, peripheral vascular disease, and ischemic stroke. It is positively correlated with weight loss, anorexiacachexia syndrome, extent of disease, and recurrence in advanced cancer. Its role as a predictor of survival has been shown in multiple myeloma, melanoma, lymphoma, ovarian, renal, pancreatic, and gastrointestinal tumors. Measurement of CRP is simple, cheap, and routine and provides valuable information in palliative care.Keywords
This publication has 64 references indexed in Scilit:
- Soluble tumour necrosis factor receptors, tumour necrosis factor and interleukin-6 in serum in granulocytopenic patients with feverBritish Journal of Haematology, 2008
- C-Reactive Protein in Ischemic StrokeStroke, 2001
- Elevated Serum Vitamin B12 Levels Associated With CRP as a Predictive Factor of Mortality in Palliative Care Cancer PatientsJournal of Pain and Symptom Management, 2000
- Acute-Phase Proteins and Other Systemic Responses to InflammationNew England Journal of Medicine, 1999
- Longitudinal study of body cell mass depletion and the inflammatory response in cancer patientsNutrition and Cancer, 1998
- Pre-operative plasma levels of C-reactive protein, albumin and various plasma protease inhibitors for the pre-operative assessment of operability and recurrence in cancer surgeryEuropean Journal of Surgical Oncology, 1996
- Serum acute phase reactants and prognosis in renal cell carcinomaCancer, 1995
- The acute phase responseImmunology Today, 1994
- Complement research: biosynthesis, genetics, immunoregulatory role and clinical studiesImmunology Today, 1992
- Histamine: an early messenger in inflammatory and immune reactionsImmunology Today, 1992