The purpose of the study to be reported here was to determine the roentgenologic appearance of argentaffinoma of the stomach and to report 4 cases of this rare tumor, 3 primary in the stomach and 1 with metastases involving that organ. Bensaid (3) states that gastric argentaffinomas represent only 1 per cent of all carcinoids. Lattes and Grossi (24) found records of only 5 carcinoids of the stomach in the Presbyterian Hospital files from 1910 to 1955. During that time 1,236 carcinomas of the stomach were encountered. To our knowledge there are now 59 published cases of gastric argentaffinoma (5, 6, 8, 12, 16, 20, 24, 29). Argentaffinomas originate from the Kulschitzky cells of the crypts of Lieberkühn, as demonstrated by Gosset and Masson (19) and Masson (33), who considered these tumors to be of endocrine origin because of the resemblance to the chromaffin cells of the paraganglia. Carcinoids appear almost exclusively below the esophagus in the gastrointestinal tract, particularly in the region of the appendix, although there have been a few instances of these tumors in ovarian teratomas (15, 35). They are also found in the bronchi (43). While appendiceal argentaffinomas are almost invariably benign, the same is not true for the extra-appendiceal variety, including gastric carcinoids (29). Of MacDonald's 149 cases of extra-appendiceal carcinoids, 16 per cent had spread to distant organs (29). In a review of 237 small bowel argentaffinomas by Ariel (1), metastases were found to be present in 59 (24.9 per cent). Forty-seven gastric argentaffinomas in which thorough pathological examination was reported included 13—approximately 30 per cent—which showed metastases. Most of the metastases were confined to the regional lymph nodes (6, 9, 21, 24, 37, 41, 46, 47). Four of the cases with metastases had hepatic deposits (9, 16, 29, 40) and 1 showed ovarian involvement (32). Consequently, whenever an argentaffinoma of the stomach is diagnosed, the possibility of its malignant nature should be considered. Even in the presence of metastasis, however, the course is apt to be slow and long-term survival possible. Three of the 5 patients with gastric argentaffinoma reported by Lattes and Grossi (24) are still living, ten, thirteen, and thirteen years after operation, in spite of the fact that 2 had histologically proved regional metastases. In fact, there appear to be only 2 cases recorded in which gastric argentaffinoma was the direct cause of death. One of these patients died of disseminated disease (40) and the other of massive and uncontrollable hemorrhage from an ulcerated gastric carcinoid (8). Argentaffinomas of the stomach can occur at almost any age. The youngest patient reported was fifteen (28) and the oldest eighty-nine (2). Most are past forty, and there is an equal sex incidence. Symptomatology is variable. Ulcer-like complaints are frequent. Seventeen tumors were incidental autopsy findings (2, 4, 9, 10, 17, 21, 34, 35, 37, 39, 41, 42).