Paradoxical Excitement following the Intravenous Administration of Azaperone in the Horse

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Abstract
The rapid i.v. administration of the butyrophenone tranquillizer, azaperone, at a dose rate of 0.29-0.57 mg/kg body weight resulted in the immediate onset of excitement and ataxia of varying degree in over half the animals. The severity of the reaction appeared to be related to the size of the animal. Other side effects such as salivation, sweating, muscle tremor and vocalization were also observed. The possible causes of this paradoxical reaction to the tranquillizer are discussed.

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