Development of Three Human Small Cell Lung Cancer Models in Nude Mice

Abstract
Most human tumors can be successfully grown in athymic nude mice (Sharkey 1978; Fiebig and Löhr 1984). Little experience has been reported on the transplantation of human small cell lung cancer (SCLC), because this tumor category is usually not treated surgically. In this paper we report on our results with transplantation of seven SCLC into nude mice. Three rapidly growing tumors were selected as tumor models. Their characteristics and responsiveness to drug treatment are described. Tumor response in the nude mouse and in the human patient is compared.

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