STEREO-ISOMERIC DISSOCIATION OF THE ANTIBACTERIAL AND THE NEUROLEPTIC EFFECT OF CLOPENTHIXOL
- 1 January 1981
- journal article
- research article
- Vol. 89 (6) , 437-438
Abstract
Measurement of the IC50 [50% inhibitory concentration] of cis(Z)-clopenthixol and trans(E)-clopenthixol on 188 bacterial strains from human clinical specimens shows that the antibacterial activity of clopenthixol is exerted by both isomerical components and trans(E)-clopenthixol is the most active antibiotic of the 2 drugs against the sensitive strains. It is known that the trans(E)-clopenthixol isomere is without neuroleptic effect. The possibility of creating new antibiotics by steric alteration of neuroleptical agents is stressed. These drugs have different antibiotic patterns from those of classical antibiotics. It seems particularly promising that Pseudomonas aeruginosa is sensitive to these drugs.This publication has 3 references indexed in Scilit:
- Experiments to Illustrate The Effect Of Chlorpromazine On The Permeability Of The Bacterial Cell WallActa Pathologica Microbiologica Scandinavica Section B Microbiology, 1979
- COMPARATIVE INVESTIGATIONS OF THE SENSITIVITY OF N. GONORRHOEAE TO PENICILLINActa Pathologica Microbiologica Scandinavica, 1963
- ELECTROCHEMICAL ASPECTS OF PHYSIOLOGICAL AND PHARMACOLOGICAL ACTION IN EXCITABLE CELLS .1. THE RESTING CELL AND ITS ALTERATION BY EXTRINSIC FACTORS1958