Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator
- 1 November 1997
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 71 (11) , 8856-8859
- https://doi.org/10.1128/jvi.71.11.8856-8859.1997
Abstract
The hepatitis C virus (HCV) nonstructural region 5A (NS5A) protein, without its 146 amino-terminal amino acids and fused to the DNA-binding domain of GAL4, strongly activates transcription in yeast and human hepatoma cells. Transcriptional activation by the HCV NS5A protein may play a role in viral replication and hepatocarcinogenesis.Keywords
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