Inhibition by Xiao‐chai‐hu‐tang (TJ‐9) of Development of Hepatic Foci Induced by N‐Nitrosomorpholine in Sprague‐Dawley Rats

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Abstract
The effect of Xiao‐chai‐hu‐tang (TJ‐9) on hepatocarcinogenesis induced by N‐nitrosomorpholine (NNM) was investigated in male Sprague‐Dawley rats. Rats were given normal chow pellets containing 0.5% or 1.0% TJ‐9 until the end of the experiment, and drinking water containing NNM for 8 weeks. Pre‐neoplastic and neoplastic lesions staining for γ‐glutamyl transpeptidase (GGT) or the placenta] type of glutathione‐S‐transferase (GST‐P) were examined histochemically. In Week 15, quantitative histological analysis showed that prolonged treatment with 0.5% TJ‐9 significantly reduced the number and volume of GGT‐positive and GST‐P‐positive hepatic lesions. Treatment with 1.0% TJ‐9 inhibited the development of GGT‐positive and GST‐P‐positive lesions, but was less effective than 0.5% TJ‐9. Administration of 0.5% TJ‐9 also caused a significant increase in the proportion of helper T lymphocytes and a significant decrease in the labeling index of pre‐neoplastic lesions. These findings indicate that TJ‐9 inhibits the development of hepatic foci.

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