Muramyl Dipeptide Induces Acute Joint Inflammation in the Mouse
- 1 July 1986
- journal article
- research article
- Published by Wiley in Microbiology and Immunology
- Vol. 30 (7) , 717-723
- https://doi.org/10.1111/j.1348-0421.1986.tb02997.x
Abstract
Acute joint inflammation was produced in BALB/c mice by a single intravenous injection of synthetic muramyl dipeptide (MDP), ist stereoisomers and 6-O-acyl derivatives of MDP. Four adjuvant-active, but not five adjuvant-inactive MDP analogs induced acute swelling and erythema of the ankles and wrists which were detected around 6-10 hr, reached the maximum severity by 18-24 hr and subsided by day 3 to 4 after injection. Introduction of the stearoyl group, but not the .alpha.-branched long chain fatty acid group into the C-9 hydroxyl group of MDP enhanced and prolonged the joint lesions compared with MDP.This publication has 18 references indexed in Scilit:
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