Coffee consumption and decreased serum gamma-glutamyltransferase and aminotransferase activities among male alcohol drinkers
- 1 June 1998
- journal article
- Published by Oxford University Press (OUP) in International Journal of Epidemiology
- Vol. 27 (3) , 438-443
- https://doi.org/10.1093/ije/27.3.438
Abstract
BACKGROUND: Attention has long been drawn to the potentially harmful effects of coffee on health, however recent epidemiological studies have suggested unexpected, possibly beneficial effects of coffee against the occurrence of alcoholic liver cirrhosis and upon serum liver enzyme levels.METHODS: We examined the potential inverse association between coffee drinking and serum concentrations of gamma-glutamyltransferase (GGT) and aminotransferases, with special reference to interaction with alcohol consumption, in a cross-sectional study involving 12687 health examinees (7398 men and 5289 women) aged 40-69 years from over 1000 workplaces in Nagano prefecture in central Japan. Those who had a history of liver disease and/or serum aminotransferases exceeding the normal range were excluded. Possible confounding effects of alcohol consumption, body mass index, cigarette smoking, and green tea consumption were controlled through multivariate analyses.RESULTS: Increased coffee consumption was strongly and independently associated with decreased GGT activity among males (P trend PMID: 9698132Keywords
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