Monoclonal Antibody to Fungal Glucosylceramide Protects Mice against LethalCryptococcus neoformansInfection
- 1 October 2007
- journal article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 14 (10) , 1372-1376
- https://doi.org/10.1128/cvi.00202-07
Abstract
Glucosylceramides (GlcCer) are involved in the regulation of Cryptococcus neoformans virulence. In the present study, we demonstrate that passive immunization with a monoclonal antibody to GlcCer significantly reduces host inflammation and prolongs the survival of mice lethally infected with C. neoformans, revealing a potential therapeutic strategy to control cryptococcosis.Keywords
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