Genealogy of cancer in a family
- 19 January 1979
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 241 (3) , 259-261
- https://doi.org/10.1001/jama.241.3.259
Abstract
Three brothers had separate childhood cancers—osteogenic sarcoma, acute lymphoblastic leukemia, and bilateral malignant neurilemoma. Comprehensive family history showed a total of 16 cases of cancer among the descendants of the proband's great-great-great-grandmother, including a previously unsuspected cluster of similar neoplasms in a distant branch. The constellation of tumors in the family included bony and soft-tissue sarcomas, brain and neural tumors, leukemia, and breast carcinoma, occurring in a pattern suggesting the action of an incompletely penetrant autosomal dominant gene with pleiotropic effects. In some cases the genetic predisposition may have interacted with environmental determinants to produce particular tumors. (JAMA241:259-261, 1979)This publication has 2 references indexed in Scilit:
- Familial Breast Cancer, Soft-Tissue Sarcomas, and Other NeoplasmsAnnals of Internal Medicine, 1975
- Soft-Tissue Sarcomas, Breast Cancer, and Other NeoplasmsAnnals of Internal Medicine, 1969