Contribution of Calcium Ions to the Generation of Epileptic Activity and Antiepileptic Calcium Antagonism
- 1 January 1993
- journal article
- review article
- Published by S. Karger AG in Neuropsychobiology
- Vol. 27 (3) , 122-126
- https://doi.org/10.1159/000118966
Abstract
With epileptic activity, neurons show paroxysmal depolarization shifts (PDSs) corresponding to epileptic field potentials (EFPs) generated by the neuronal population. Experimental results indicate that calcium and calcium-dependent currents participate in the generation of these events. Consequently neuronal PDS/EFP were depressed by organic calcium channel blockers. This justifies the hope that calcium channel blockers might be useful in the treatment of human epilepsies.Keywords
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