Pharmacokinetics of imidocarb in normal dogs and goats

Publisher Website
Google Scholar
Abstract
The pharmacokinetics of imidocarb were studied in seven mongrel dogs and eight crossbred goats. An intravenous bolus dose (4 mg/kg) of 12% imidocarb dipropionate solution wasinjected into the cephalic vein in dogs and the jugular vein in goats. The plasma concentration of imidocarb was measured by spectro‐photometry. The experimental data were analysed using a two‐compartment open model. The apparent volume of the central compartment was significantly higher (PPt1/2, 207 ± 45 min; ClB, 1.47 ± 0.38 ml/min kg) and goats (t1/2, 251 ± 94 min; ClB, 1.62 ± 0.50 ml/min kg). While almost 80% of the dose had been eliminated at 8 h in. both species, the high ratio of the imidocarb level in the peripheral‐to‐central compartment in goats suggests that a prolonged period may be required for complete elimination of the drug.