Improved Formulae for the Judgement of Intrathecal Produced IgA and IgM in the Presence of Blood CSF Barrier Damage
- 1 September 1993
- journal article
- Published by SAGE Publications in Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
- Vol. 30 (5) , 454-462
- https://doi.org/10.1177/000456329303000507
Abstract
In order to discriminate between transsudated and intrathecally produced IgA and IgM in patients with blood cerebrospinal fluid (CSF) barrier (BCB) damage, we developed extended indices (IgA-EI and IgM-EI) for these immunoglobulins according to the general formula for extended index of a component X in CSF: where a is a parameter specific for X. For IgA parameter a was found to be 1·15 and for IgM 1·9. A preliminary evaluation of IgA-EI and IgM-EI indicated lower false positive rates as compared to CSF IgA and IgM concentrations as well as ‘conventional’ IgA and IgM indices in cases with BCB damage, and essentially the same rates as for the hyperbolic formulae of Reiber and Felgenhauer. The importance of reliable sampling and analytical technique for IgM in CSF is discussed.Keywords
This publication has 18 references indexed in Scilit:
- Comparison of Seven Formulae and Isoelectrofocusing for Determination of Intrathecally Produced IgG in Neurological DiseasesAnnals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1992
- Diagnostic Usefulness of Cerebrospinal Fluid in Multiple SclerosisCritical Reviews in Clinical Laboratory Sciences, 1991
- Intrathecal synthesis of IgM in neurological diseases: A comparison between detection of oligoclonal bands and quantitative estimationJournal of the Neurological Sciences, 1990
- An improved formula for the judgement of intrathecally produced IgG in the presence of blood brain barrier damageClinica Chimica Acta; International Journal of Clinical Chemistry, 1989
- Cerebrospinal Fluid Immunoglobulins and 2-Microglobulin in Lymphoproliferative and Other Neoplastic Diseases of the Central Nervous SystemArchives of Neurology, 1987
- Protein transfer at the blood cerebrospinal fluid barrier and the quantitation of the humoral immune response within the central nervous systemClinica Chimica Acta; International Journal of Clinical Chemistry, 1987
- The compartmental IgM and IgA response within the central nervous systemJournal of the Neurological Sciences, 1987
- Cerebrospinal fluid immunoglobulin abnormalities in systemic lupus erythematosus.Journal of Neurology, Neurosurgery & Psychiatry, 1985
- Reference values for CSF-IgM, CSF-IgM/S-IgM ratio and IgM index, and its application to patients with multiple sclerosis and aseptic meningoencephalitisScandinavian Journal of Clinical and Laboratory Investigation, 1984
- AnnouncementsAnnals of Neurology, 1978