Mechanism of inhibition of mammalian tumor and other thymidylate synthases by N4-hydroxy-dCMP, N4-hydroxy-5-fluoro-dCMP, and related analogs
- 4 December 1990
- journal article
- research article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 29 (48) , 10835-10842
- https://doi.org/10.1021/bi00500a017
Abstract
Note: In lieu of an abstract, this is the article's first page.Keywords
This publication has 25 references indexed in Scilit:
- The structure of sodium β-fluoropyruvate: A gem-DiolArchives of Biochemistry and Biophysics, 1979
- Fluorinated substrate analogs as stereochemical probes of enzymic reaction mechanismsBiochemistry, 1978
- Thymidylate synthetase - a target enzyme in cancer chemotherapyBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1977
- Mechanism of hydroxylamine mutagenesis Crystal structure and conformation of 1,5-dimethyl-N4-hydroxycytosineBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1976
- Nucleosides. XLVII. Syntheses of some N4-substituted derivatives of 1-.beta.-D-arabinofuranosylcytosine and -5-fluorocytosineJournal of Medicinal Chemistry, 1968
- The Purification and Properties of Thymidylate Synthetase from Chick Embryo ExtractsJournal of Biological Chemistry, 1967
- MUTAGENICITY OF HYDROXYLAMINE - REACTION WITH ANALOGUES OF CYTOSINE 5(6)-SUBSTITUTED CYTOSINES AND SOME 2-KETO-4-ETHOXYPYRIMIDINES1965
- The Purification and Properties of Deoxycytidylate Deaminase from Chick Embryo ExtractsJournal of Biological Chemistry, 1964
- ULTRAVIOLET ABSORPTION SPECTRA AND STRUCTURE OF HALOGENATED URACILS AND THEIR GLYCOSIDES1963
- Direct Spectrophotometric Evidence for the Oxidation of Tetrahydrofolate during the Enzymatic Synthesis of ThymidylateJournal of Biological Chemistry, 1961