1ST EXPERIENCES WITH BS 100-141, A NEW ANTIHYPERTENSIVE SUBSTANCE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 14  (2) , 109-112
Abstract
The administration of a new guanidine derivate, BS 100-141 [N-amidino-2(2,6-dichlorophenyl)acetamide hydrochloride] to 20 patients resulted in a statistically highly significant reduction of blood pressure. A comparative clinical trial of BS 100-141 and .alpha.-methyl-dopa showed BS 100-141 to be more efficient in lowering the arterial pressure than .alpha.-methyl-dopa, especially when the drug was used in the 2nd period of treatment. In the majority of the patients treated with BS 100-141, a slight increase in blood glucose concentration, not exceeding the upper limits of normal values, was found.

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