Reactivity of 2‐amino‐1,3,4‐thiadiazoles. Methylation reactions of some 2‐amino‐5‐benzoyl‐1,3,4‐thiadiazoles
- 1 October 1975
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 12 (5) , 841-844
- https://doi.org/10.1002/jhet.5570120506
Abstract
Methylation reactions of 2‐amino‐5‐benzoyl‐1,3,4‐thiadiazoles 1a‐d are reported as a function of alkylating agents (methyl iodide, dimethyl sulfate‐potassium carbonate, diazomethane, dimethyl‐sulfate‐sodium methoxide). Methylation occurs at both the ring nitrogen in position 3 and the exocyclic nitrogen atom.Keywords
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