The Relation of Vitamin B12 and Folacin to the Utilization of Choline and its Precursors for Lipotropism and Renal Protection in Rats

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Abstract
The choline requirement of rats for the maintenance of normal liver fat is greatly reduced by supplementing the diet with vitamin B12 and folacin. For lipotropism and protection against renal damage in rats, vitamin B12 and folacin increased the efficiency of betaine, DL-methionine, dimethylaminoethanol, and methylaminoethanol as replacements for dietary choline. The triethylhomologue of choline fed to weanling rats is not capable of replacing choline as a lipotropic agent. Vitamin B12 and folacin appear to be essential for the maximum utilization of methionine or betaine for the biological synthesis of choline from aminoethanol or methylaminoethanol.

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