Parallel changes in Glut 4 and Rab4 movements in two insulin‐resistant states

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Abstract
Insulin‐induced Glut 4 and Rab4 movements were studied in two insulin‐resistant states. In adipocytes from streptozotocin diabetic rats, the amount of Glut 4 was decreased by 60%. The remaining Glut 4 molecules were translocated in response to insulin, and in parallel, Rab4 left the intracellular compartment. In contrast, in 3T3‐L1 adipocytes rendered insulin‐resistant by a prolonged insulin treatment, both Rab4 and Glut 4 remained in the intracellular compartment following an acute insulin stimulation. Those results illustrate a similar behavior of Glut 4 and Rab4 in two situations where insulin resistance results from different mechanisms, and add further support for a role of Rab4 in Glut 4 transiocation.