The Formation of Phenylethane-1,2-diol 2-Acetate in the Metabolism of Styrene Oxide by Rabbit Liver Microsomesin vitro
- 1 January 1979
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 9 (1) , 57-61
- https://doi.org/10.3109/00498257909034704
Abstract
1. Phenylethane-1,2-diol 2-acetate has been isolated from the incubation of styrene oxide or styrene diol with liver microsomes of phenobarbital-pretreated rabbits. 2. Observed ratios of phenylethane-1,2-diol to its 2-acetate in the incubation mixtures ranged between 19:1 and 5 : 1 with different microsomal preparations and different periods of incubation. 3. The formation of phenylethane-1,2-diol 2-acetate may be a source of errors in the radiometric determination of epoxide hydrase activity in microsomes.This publication has 11 references indexed in Scilit:
- The apparent ubiquity of epoxide hydratase in rat organsBiochemical Pharmacology, 1977
- A specific gas chromatographic method for the determination of microsomal styrene monooxygenase and styrene epoxide hydratase activitiesJournal of Chromatography A, 1976
- Metabolism and toxicity of styrene.Environmental Health Perspectives, 1975
- Epoxides in Polycyclic Aromatic Hydrocarbon Metabolism and CarcinogenesisAdvances in Cancer Research, 1974
- Mammalian Epoxide Hydrases: Inducible Enzymes Catalysing the Inactivation of Carcinogenic and Cytotoxic Metabolites Derived from Aromatic and Olefinic CompoundsXenobiotica, 1973
- Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compoundsCellular and Molecular Life Sciences, 1972
- A radiometric assay for hepatic epoxide hydrase activity with [7-3H] styrene oxideBiochimica et Biophysica Acta (BBA) - Enzymology, 1971
- 3 Carboxylic Ester HydrolasesPublished by Elsevier ,1971
- Role of the arene oxide-oxepin system in the metabolism of aromatic substrates. IV. Stereochemical considerations of dihydrodiol formation and dehyrogenationJournal of the American Chemical Society, 1970
- Role of the arene oxide-oxepin system in the metabolism of aromatic substratesArchives of Biochemistry and Biophysics, 1968